PRECURSOR LYMPHOID NEOPLASMS

  • B-lymphoblastic leukemia/lymphoma
    • B-lymphoblastic leukemia/lymphoma, not otherwise specified
    • B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
      • B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
      • B-lymphoblastic leukemia/lymphoma with t(v;11q23.3); KMT2A rearranged
      • B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
      • B-lymphoblastic leukemia/lymphoma with hyperdiploidy
      • B-lymphoblastic leukemia/lymphoma with hypodiploidy
      • B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH
      • B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1
      • B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like (provisional entity)
      • B-lymphoblastic leukemia/lymphoma with iAMP21 (provisional entity)
  • T-lymphoblastic leukemia/lymphoma
    • early T-cell precursor lymphoblastic leukemia (provisional entity)
  • natural killer (NK) cell lymphoblastic leukemia/lymphoma (provisional entity)

 

MATURE B-CELL NEOPLASMS

  • chronic lymphocytic leukemia/small lymphocytic lymphoma
  • monoclonal B-cell lymphocytosis
  • B-cell prolymphocytic leukemia
  • splenic marginal zone lymphoma
  • hairy cell leukemia
  • splenic B-cell lymphoma/leukemia, unclassifiable
    • splenic diffuse red pulp small B-cell lymphoma (provisional entity)
    • hairy cell leukemia-variant (provisional entity)
  • lymphoplasmacytic lymphoma
    • Waldenström macroglobulinemia
  • IgM monoclonal gammopathy of undetermined significance
  • heavy-chain diseases
    • μ heavy-chain disease
    • γ heavy-chain disease
    • α heavy-chain disease
  • plasma cell neoplasms
    • non-IgM monoclonal gammopathy of undetermined significance (IgG/A)
    • plasma cell myeloma
    • plasma cell myeloma variants
      • smoldering (asymptomatic) plasma cell myeloma
      • non-secretory myeloma
      • plasma cell leukemia
    • plasmacytoma
      • solitary plasmacytoma of bone
      • extraosseous plasmacytoma
    • monoclonal immunoglobulin deposition diseases
      • primary amyloidosis
      • light chain and heavy chain deposition diseases
    • plasma cell neoplasms with associated paraneoplastic syndrome
      • POEMS syndrome
      • TEMPI syndrome
  • extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
  • nodal marginal zone lymphoma
    • pediatric nodal marginal zone lymphoma (provisional entity)
  • follicular lymphoma
    • testicular follicular lymphoma
    • in situ follicular neoplasia
    • duodenal-type follicular lymphoma
  • pediatric-type follicular lymphoma
  • large B-cell lymphoma with IRF4 rearrangement (provisional entity)
  • primary cutaneous follicle center lymphoma
  • mantle cell lymphoma
    • leukemic non-nodal mantle cell lymphoma
    • in situ mantle cell neoplasia
  • diffuse large B-cell lymphoma, not otherwise specified
    • germinal center B-cell type
    • activated B-cell type
  • T-cell/histiocyte-rich large B-cell lymphoma
  • primary diffuse large B-cell lymphoma of the central nervous system
  • primary cutaneous diffuse large B-cell lymphoma, leg type
  • EBV-positive diffuse large B-cell lymphoma, not otherwise specified
  • EBV-positive mucocutaneous ulcer (provisional entity)
  • diffuse large B-cell lymphoma associated with chronic inflammation
    • fibrin-associated diffuse large B-cell lymphoma
  • lymphomatoid granulomatosis
  • primary mediastinal (thymic) large B-cell lymphoma
  • intravascular large B-cell lymphoma
  • ALK-positive large B-cell lymphoma
  • plasmablastic lymphoma
  • primary effusion lymphoma
  • HHV8-associated lymphoproliferative disorders
    • multicentric Castleman disease
    • HHV8-positive diffuse large B-cell lymphoma, not otherwise specified (provisional entity)
    • HHV8-positive germinotropic lymphoproliferative disorder
  • Burkitt lymphoma
  • Burkitt-like lymphoma with 11q aberration (provisional entity)
  • high-grade B-cell lymphoma
    • high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
    • high-grade B-cell lymphoma, not otherwise specified
  • B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

 

MATURE T- and NK-CELL NEOPLASMS

  • T-cell prolymphocytic leukemia
  • T-cell large granular lymphocytic leukemia
  • chronic lymphoproliferative disorder of NK cells (provisional entity)
  • aggressive NK-cell leukemia
  • EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood
    • systemic EBV-positive T-cell lymphoma of childhood
    • chronic active EBV infection of T- and NK-cell type, systemic form
    • hydroa vacciniforme–like lymphoproliferative disorder
    • severe mosquito bite allergy
  • adult T-cell leukemia/lymphoma
  • extranodal NK-/T-cell lymphoma, nasal type
  • intestinal T-cell lymphoma
    • enteropathy-associated T-cell lymphoma
    • monomorphic epitheliotropic intestinal T-cell lymphoma
    • intestinal T-cell lymphoma, not otherwise specified
    • indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (provisional entity)
  • hepatosplenic T-cell lymphoma
  • subcutaneous panniculitis-like T-cell lymphoma
  • mycosis fungoides
  • Sézary syndrome
  • primary cutaneous CD30+ T-cell lymphoproliferative disorders
    • lymphomatoid papulosis
    • primary cutaneous anaplastic large cell lymphoma
  • primary cutaneous peripheral T-cell lymphomas, rare subtypes
    • primary cutaneous γδ T-cell lymphoma
    • primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional entity)
    • primary cutaneous acral CD8+ T-cell lymphoma (provisional entity)
    • primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (provisional entity)
  • peripheral T-cell lymphoma, not otherwise specified
  • angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin
    • angioimmunoblastic T-cell lymphoma
    • follicular T-cell lymphoma (provisional entity)
    • nodal peripheral T-cell lymphoma with T follicular helper phenotype (provisional entity)
  • anaplastic large-cell lymphoma, ALK-positive
  • anaplastic large-cell lymphoma, ALK-negative
  • breast implant-associated anaplastic large-cell lymphoma (provisional entity)

 

HODGKIN LYMPHOMAS

  • nodular lymphocyte predominant Hodgkin lymphoma
  • classical Hodgkin lymphoma
    • nodular sclerosis classical Hodgkin lymphoma
    • lymphocyte-rich classical Hodgkin lymphoma
    • mixed cellularity classical Hodgkin lymphoma
    • lymphocyte-depleted classical Hodgkin lymphoma

 

IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS

  • plasmacytic hyperplasia PTLD
  • infectious mononucleosis PTLD
  • florid follicular hyperplasia PTLD
  • polymorphic PTLD
  • monomorphic PTLD
    • monomorphic B-cell PTLD
    • monomorphic T/NK-cell PTLD
  • classical Hodgkin lymphoma PTLD

 

Bibliografía


Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds): WHO CLASSIFICATION OF TUMOURS OF HAEMATOPOIETIC AND LYMPHOID TISSUES (Revised 4th edition). IARC:  Lyon 2017